Items truly must be precisely tried and make beyond any doubt it's great in that sort of thing so uh... one I think huge changes that in the most recent ten years we're getting naked therapeutics Cogniflex based Michael antibodies they're coming and getting sanction by the f_d_a_ and it’s I would say in the request of three to five new ones consistently and I don't mean me too move sorts of treatment zany novel therapies expressions of new…