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Furosemide, like other furosemide loop diuretics, acts by inhibiting NKCC2, the luminal Na-K-Cl cotransporter in the thick ascending limb of the loop of Henle . The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also furosemide abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance .

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