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High doses ( > 80 mg) of furosemide may inhibit the binding of thyroid hormones to carrier proteins and result in transient increase in free thyroid furosemide hormones, followed by an overall decrease in total thyroid hormone levels .
Literature furosemide reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of LASIX (furosemide) in some patients by inhibiting prostaglandin synthesis . Patients receiving both indomethacin and LASIX should be observed closely to determine if the desired diuretic and/or antihypertensive effect of LASIX furosemide is achieved . Indomethacin may also affect plasma renin furosemide action furosemide effects on kidneys what does furosemide treat furosemide 4 mg levels, aldosterone excretion, and renin profile evaluation .

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